HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.

antiretroviral therapy, drug resistance, epidemiology, genotyping, HIV-1
dx.doi.org/10.1093/infdis/jit017, hdl.handle.net/1765/64834
The Journal of Infectious Diseases
Department of Virology

Luca, A, Dunn, D, Zazzi, M, Camacho, R.J, Torti, C, Fanti, I, … di Giambenedetto, S. (2013). Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe. The Journal of Infectious Diseases, 207(8), 1216–1220. doi:10.1093/infdis/jit017