Objective: To describe causes of death in the first year after esophagectomy and determine the time frame that should be used for measurement of quality of surgery. A case-mix adjustment model was developed for the comparison between hospitals. Background: The time period in which postoperative mortality should be measured as a performance indicator is debated. Methods: Cause of death was identified for patients in a tertiary referral hospital who died within 1 year after surgery and classified as surgery related or not surgery related. Sensitivity and specificity for detecting deaths related to surgery were calculated for different periods of follow-up. Case-mix adjustment models for 30-day mortality (30DM), in-hospital mortality, and 90-day mortality (90DM) were developed. Results: In total, 1282 patients underwent esophagectomy. 30DM was 2.9%, the in-hospital mortality rate was 5.1% and 90DM was 7%. Beyond 30 days, a substantial number of deaths were related to the operation, especially due to anastomotic leakage. Postdischarge nononcological mortality was most frequently caused by sudden death. One in 5 patients died because of recurrent disease, being the most important threat in the first year after surgery. The 30DM had a sensitivity for detecting surgery-related deaths of 33% and a specificity of 100%. The 90DM had a sensitivity of 74% and a specificity of 96%. Conclusions: A period of postoperative follow-up longer than 30 days needs to be considered when comparing surgical performance between institutes. In the case-mix adjustment model for 90DM, no other variables have to be taken into account compared to those involved in 30DM. Copyright

30-day mortality, 90-day mortality, Causes of death, Esophageal cancer surgery, In-hospital mortality
dx.doi.org/10.1097/SLA.0000000000000482, hdl.handle.net/1765/65036
Annals of Surgery
Department of Surgery

Talsma, A.K, Lingsma, H.F, Steyerberg, E.W, Wijnhoven, B.P.L, & van Lanschot, J.J.B. (2014). The 30-day versus in-hospital and 90-day mortality after esophagectomy as indicators for quality of care. Annals of Surgery, 260(2), 267–273. doi:10.1097/SLA.0000000000000482