Local hyperthermia is an effective treatment modality to augment radio- and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents.

DNA double-strand breaks, Heat-shock protein inhibitors, Homologous recombination, Hyperthermia, PARP inhibitors
dx.doi.org/10.3109/02656736.2012.695427, hdl.handle.net/1765/65074
International Journal of Hyperthermia
Department of Molecular Genetics

Eppink, B, Krawczyk, P.M, Stap, J, & Kanaar, R. (2012). Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies. International Journal of Hyperthermia, 28(6), 509–517. doi:10.3109/02656736.2012.695427