This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48h (sleep vs. no-sleep nights) in 12 young males (mean±SD: 23±5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e.g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation.

Circadian clock, Circadian rhythms, Clock genes, Oxidative stress, Sleep deprivation
dx.doi.org/10.3109/07420528.2013.784773, hdl.handle.net/1765/65250
Chronobiology International
Centre for Rotterdam Cultural Sociology (CROCUS)

Ackermann, K, Plomp, R, Lao Grueso, O, Middleton, B, Revell, V.L, Skene, D.J, & Kayser, M.H. (2013). Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans. Chronobiology International, 30(7), 901–909. doi:10.3109/07420528.2013.784773