The aim of this study was to assess the referral pattern and the impact on long-term survival of postoperative radiotherapy in patients with adenocarcinoma of the endometrium stage I. This was a retrospective study performed in a regional cancer registry which covers a population of approximately 1 000 000 persons. All 724 patients registered between 1975 and 1992 in the Comprehensive Cancer Centre South, Eastern Section, The Netherlands, were analysed. All patients had received surgery as primary treatment which was performed in one of the seven community hospitals of the region. Radiotherapy was given in one regional department. All pathology reports were checked for data on tumour differentiation and myometrial invasion. Almost haft the patients (45%) were referred for postoperative radiotherapy. The depth of myometrial invasion and the degree of tin our differentiation were the main factors (P < 0.0001) influencing referral for postoperative radiotherapy. The referral pattern varied between the different hospitals, but became more similar during 1985-1988, to diverge again in recent years. In patients younger than 60 years, the depth of myometrial invasion was significantly (P = 0.01) correlated with survival. In patients older than 60 years, tumour differentiation (P = 0.05) and age (P < 0.001) were correlated with survival, but not the depth of myometrial invasion. After adjustment for known prognostic factors, a survival benefit of postoperative radiotherapy could not be established. The studied group had an excess death rate over the normal Dutch female population. This excess death rate did not decrease during follow-up, as even after 10 years an excess death rate was found. A prospective randomised trial is ongoing in The Netherlands.

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European Journal of Cancer
Erasmus MC: University Medical Center Rotterdam

Lybeert, M., van Putten, W., Brölmann, H. A. M., & Coebergh, J. W. (1998). Postoperative radiotherapy for endometrial carcinoma stage I. Wide variation in referral patterns but no effect on long-term survival in a retrospective study in the Southeast Netherlands. European Journal of Cancer, 34(4), 586–590. doi:10.1016/S0959-8049(97)10087-9