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A.C.J. Stork (Abraham), B.C. Jacobs (Bart), A.P. Tio-Gillen (Anne), M. Eurelings (Marijke), M. Jansen (Marc), L.H. van den Berg (Leonard), N.C. Notermans (Nicolette) and W.-L. van der Pol (W-Ludo)

2014-02-13

Prevalence, specificity and functionality of anti-ganglioside antibodies in neuropathy associated with IgM monoclonal gammopathy

Publication

Publication

Journal of Neuroimmunology , Volume 268 - Issue 1-2 p. 89- 94

IgM antibodies against gangliosides and their complexes were studied in sera from 54 patients with polyneuropathy and IgM monoclonal gammopathy (IgM-PNP) without anti-MAG antibodies. Anti-ganglioside antibodies were found in 19 (35%) patients. Five (9%) patients had antibodies against ganglioside complexes. IgM antibodies against gangliosides activated complement in vitro. Light chain usage was restricted to kappa or lambda in most, but not all patients.In conclusion, anti-ganglioside antibodies in IgM-PNP are common, display pathogenic properties and do not always arise from a monoclonal B cell proliferation.

Additional Metadata
Keywords Ganglioside, Hematologic disease, Immunology, Monoclonal gammopathy of unknown significance, Peripheral neuropathy
Persistent URL doi.org/10.1016/j.jneuroim.2014.01.012, hdl.handle.net/1765/65287
Journal Journal of Neuroimmunology
Organisation Department of Neurology
Citation
Stork, A.C.J, Jacobs, B.C, Tio-Gillen, A.P, Eurelings, M, Jansen, M, van den Berg, L.H, … van der Pol, W.-L. (2014). Prevalence, specificity and functionality of anti-ganglioside antibodies in neuropathy associated with IgM monoclonal gammopathy. Journal of Neuroimmunology, 268(1-2), 89–94. doi:10.1016/j.jneuroim.2014.01.012


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