Background: Inflammatory processes during pregnancy might affect fetal lung development and immune responses. We examined the associations of maternal and cord blood C-reactive protein levels with respiratory symptoms and eczema in preschool children. Methods: This study was embedded in a population-based prospective cohort study of 4984 children. Generalized estimating equations were used to assess the effect of C-reactive protein levels on respiratory symptoms or eczema. C-reactive protein levels were measured during early pregnancy and at birth. Wheezing, lower respiratory tract infections, and eczema until the age of 4 yr were annually obtained by questionnaires. Results: Maternal C-reactive protein was not associated with the risks of wheezing and lower respiratory tract infections. Compared to children with maternal C-reactive protein in the lowest quarter, children in the highest quarter had increased risks of eczema OR 1.20 (1.03, 1.40). Compared to children with cord blood C-reactive protein lower than 0.20 mg/l, those with levels higher than 0.20 mg/l had increased risks of wheezing, OR 1.21 (1.07, 1.36), and lower respiratory tract infections, OR 1.21 (1.05, 1.39), but not of eczema. Conclusions: Our results suggest that elevated maternal C-reactive protein in pregnancy is associated with a higher risk of eczema, and C-reactive protein in cord blood with a higher risk of wheezing and lower respiratory tract infections in the first 4 yrs.

Asthma, Cohort study, Eczema, Respiratory infections, Wheezing,
Pediatric Allergy and Immunology
Department of Pediatrics

van der Sonnenschein-Voort, A.M.M, Jaddoe, V.W.V, Moll, H.A, Hofman, A, van der Valk, R.J.P, de Jongste, J.C, & Duijts, L. (2013). Influence of maternal and cord blood C-reactive protein on childhood respiratory symptoms and eczema. Pediatric Allergy and Immunology, 24(5), 469–475. doi:10.1111/pai.12094