The number of metabolites identified in human cerebrospinal fluid (CSF) has steadily increased over the past 5 years, and in this issue of Genome Medicine David Wishart and colleagues provide a comprehensive update that brings the number of metabolites listed in the CSF metabolome database to 476 compounds. There is now a need for an integrative metabolome-proteome CSF database to maximize the impact of this achievement in biomedical research. Only by such efforts can we hope to unravel the complexity of molecular pathophysiological processes.

dx.doi.org/10.1186/gm338, hdl.handle.net/1765/65468
Genome Medicine
Department of Neuroscience

Schwarz, E, Torrey, F.E, Guest, P.C, & Bahn, S. (2012). Biomarker discovery in human cerebrospinal fluid: The need for integrative metabolome and proteome databases. Genome Medicine (Vol. 4). doi:10.1186/gm338