The number of metabolites identified in human cerebrospinal fluid (CSF) has steadily increased over the past 5 years, and in this issue of Genome Medicine David Wishart and colleagues provide a comprehensive update that brings the number of metabolites listed in the CSF metabolome database to 476 compounds. There is now a need for an integrative metabolome-proteome CSF database to maximize the impact of this achievement in biomedical research. Only by such efforts can we hope to unravel the complexity of molecular pathophysiological processes.,
Genome Medicine
Department of Neuroscience

Schwarz, E, Torrey, F.E, Guest, P.C, & Bahn, S. (2012). Biomarker discovery in human cerebrospinal fluid: The need for integrative metabolome and proteome databases. Genome Medicine (Vol. 4). doi:10.1186/gm338