This case report describes a patient on tranylcypromine who erroneously received a single dose of imipramine and subsequently developed a fatal serotonin syndrome. Both the clinical features and the pathophysiology of the serotonin syndrome are discussed.

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European Psychiatry
Department of Psychiatry

Otte, W, Birkenhäger, T.K, & van den Broek, W.W. (2003). Fatal interaction between tranylcypromine and imipramine. European Psychiatry, 18(5), 264–265. doi:10.1016/S0924-9338(03)00090-7