We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing different stages of disease. A 1:25mm diameter intravascular imaging catheter was built, comprising an angle-polished optical fiber adjacent to a 30 MHz ultrasound transducer. Specific photoacoustic imaging of lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230nm. Simultaneous imaging with intravascular ultrasound was performed. 2011 Optical Society of America.

doi.org/10.1364/OL.36.000597, hdl.handle.net/1765/65625
Optics Letters
Department of Pathology

Jansen, K., van der Steen, T., van Beusekom, H., Oosterhuis, W., & van Soest, G. (2011). Intravascular photoacoustic imaging of human coronary atherosclerosis. Optics Letters, 36(5), 597–599. doi:10.1364/OL.36.000597