Objective To evaluate the influence of oral contraceptive pills (OCPs) on anthromorphometric, endocrine, and metabolic parameters in women with polycystic ovary syndrome (PCOS). Design Retrospective cross-sectional cohort study for the period 1993-2011. Setting Tertiary university hospital. Patient(s) PCOS patients, who never, ever, or at time of screening were using OCPs were included. A total of 1,297 patients, of whom 827 were white, were included. All PCOS patients diagnosed according to the Rotterdam 2003 consensus criteria were divided into three groups: current users, (n = 76; 6% of total), ever users (n = 1,018; 78%), and never users (n = 203; 16%). Ever users were subdivided based on the OCP-free interval. Intervention(s) None. Main Outcome Measure(s) Anthromorphometric (blood pressure, cycle duration) and ultrasound (follicle count, mean ovarian volume) parameters, endocrine (SHBG, testosterone, free androgen index, antim├╝llerian hormone [AMH]) and lipid profiles. Result(s) Current users and ever users were compared with never users. In current users, SHBG was increased and androgen levels decreased. Patients with an OCP-free interval of <1 year had a higher mean follicle count, higher AMH level, and increased serum androgen level compared with never users. SHBG levels remained increased until 5-10 years after cessation of OCP use. Conclusion(s) OCP use causes a milder phenotypic presentation of PCOS regarding hyperandrogenism. However, it does not alter parameters associated with increased health risks. Copyright

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doi.org/10.1016/j.fertnstert.2014.02.039, hdl.handle.net/1765/65671
Fertility and Sterility
Department of Gynaecology & Obstetrics

Mes-Krowinkel, M., Louwers, Y., Mulders, A., de Jong, F., Fauser, B., & Laven, J. (2014). Influence of oral contraceptives on anthropomorphometric, endocrine, and metabolic profiles of anovulatory polycystic ovary syndrome patients. Fertility and Sterility, 101(6). doi:10.1016/j.fertnstert.2014.02.039