In the Fmr1 knockout mice, a model for fragile X mental retardation syndrome, the levels of regulator of G-protein signaling (Rgs) 4 but not Rgs2 mRNA were considerably reduced (65% from control) in the cerebral cortex and hippocampal CA1 region. The expression of Rgs4 was normal in animals lacking a related protein, FXR2P, indicating that the decrease in Rgs4 expression was specific for the absence of FMRP, and suggests a role for FMRP in G-protein signaling.

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Molecular Brain Research
Department of Clinical Genetics

Tervonen, T, Åkerman, K, Oostra, B.A, & Castrén, M. (2005). Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse. Molecular Brain Research, 133(1), 162–165. doi:10.1016/j.molbrainres.2004.09.023