We describe a 33-year-old woman, who presented with lowered consciousness level and seizures, due to cerebral venous sinus thrombosis with venous haemorrhagic infarcts. The patient, who was taking oral contraceptives, appeared to be heterozygous for a prothrombin gene variant, which is due to a G→A transition at position 20210. This 20210A prothrombin has recently been established as an important risk factor for cerebral venous sinus thrombosis, which interacts with oral contraceptive use. Copyright (C) 1999 Elsevier Science B.V.

Prothrombin, Sinus thrombosis
dx.doi.org/10.1016/S0303-8467(99)00003-7, hdl.handle.net/1765/65931
Clinical Neurology and Neurosurgery
Department of Neurology

van Krimpen, J, Leebeek, F.W.G, Dippel, D.W.J, & Gómez García, E.B. (1999). Prothrombin gene variant (G20210A) in a patient with cerebral venous sinus thrombosis. Clinical Neurology and Neurosurgery, 101(1), 53–55. doi:10.1016/S0303-8467(99)00003-7