2004-10-18
Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN
Publication
Publication
The Journal of Experimental Medicine , Volume 200 - Issue 8 p. 979- 990
The human gastric pathogen Helicobacter pylori spontaneously switches lipopolysaccharide (LPS) Lewis (Le) antigens on and off (phase-variable expression), but the biological significance of this is unclear. Here, we report that Le+ H. pylori variants are able to bind to the C-type lectin DC-SIGN and present on gastric dendritic cells (DCs), and demonstrate that this interaction blocks T helper cell (Th)1 development. In contrast, Le- variants escape binding to DCs and induce a strong Th1 cell response. In addition, in gastric biopsies challenged ex vivo with Le+ variants that bind DC-SIGN, interleukin 6 production is decreased, indicative of increased immune suppression. Our data indicate a role for LPS phase variation and Le antigen expression by H. pylori in suppressing immune responses through DC-SIGN.
Additional Metadata | |
---|---|
, , , , | |
doi.org/10.1084/jem.20041061, hdl.handle.net/1765/65939 | |
The Journal of Experimental Medicine | |
Organisation | Department of Medical Microbiology and Infectious Diseases |
Bergman, M., Appelmelk, B., Engering, A., Smits, H., van Vliet, S., van Bodegraven, A., … van Kooyk, Y. (2004). Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN. The Journal of Experimental Medicine, 200(8), 979–990. doi:10.1084/jem.20041061 |