The currently available long-acting somatostatin analogs normalize serum growth hormone (GH) levels and insulin-like growth factor-I levels in approximately 60% of patients with acromegaly. The recently introduced GH receptor antagonist, pegvisomant, is able to normalize insulin-like growth factor-I levels in virtually all acromegalic subjects. Although no correlation between increased GH concentrations and tumor size has been found, long-term safety studies are still in progress. Also, pegvisomant monotherapy is administered once daily and is very costly. Combined treatment of a somatostatin analog with pegvisomant appears to be an effective and rational approach. Copyright

Additional Metadata
Keywords Growth hormone receptor, Pegvisomant, Somatostatin analog
Persistent URL dx.doi.org/10.1159/000095537, hdl.handle.net/1765/65965
Journal Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships
Citation
van der Lely, A-J, & Kopchick, J.J. (2006). Growth hormone receptor antagonists. In Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships (Vol. 83, pp. 264–268). doi:10.1159/000095537