Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.

Chemotherapy, Oncology
dx.doi.org/10.1006/jsre.1997.5256, hdl.handle.net/1765/65999
Journal of Surgical Research
Department of Surgery

Manusama, E.R, Nooijen, P.T.G.A, Stavast, J, de Wilt, J.H.W, Marquet, R.L, & Eggermont, A.M.M. (1998). Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats. Journal of Surgical Research, 78(2), 169–175. doi:10.1006/jsre.1997.5256