Background: The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design: An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and were followed up for events. Methods: Subjects were divided into a development and internal validation dataset and an external validation dataset. Two models, comprising FRS and FRS+ABI, were fitted for the primary outcome of major coronary events.

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Keywords Ankle brachial index, cardiovascular diseases, risk assessment
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Journal European Journal of Preventive Cardiology
Fowkes, F.G.R, Murray, G.D, Butcher, I, Folsom, A.R, Hirsch, A.T, Couper, D.J, … Hamman, U. (2014). Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. European Journal of Preventive Cardiology, 21(3), 310–320. doi:10.1177/2047487313516564