Objective: To validate a previously published prediction model for recurrent early-onset preeclampsia (PE). Methods: We included 229 pregnant women with a history of early-onset PE and computed their risk using the prediction model, compared the predicted risk to their pregnancy outcomes and assessed performance of the model. Results: Early-onset PE recurred in 6.6% of participants. The area under the receiver operating characteristic curve was 59% (95% CI: 45-73). The model created groups that were only moderately different in terms of their risk. Conclusions: The model's discriminate ability was poor and predictive performance insufficient to classify women into relevant risk groups.

Early-onset, External validation, Prediction, Preeclampsia, Recurrence.
dx.doi.org/10.3109/10641955.2013.872253, hdl.handle.net/1765/66284
Hypertension in Pregnancy
Department of Gynaecology & Obstetrics

van Kuijk, S.M.J, Delahaije, D.H.J, Dirksen, C.D, Scheepers, H.C.J, Spaanderman, M.E.A, Ganzevoort, W, … Smits, L.J. (2014). External validation of a model for periconceptional prediction of recurrent early-onset preeclampsia. Hypertension in Pregnancy, 33(3), 265–276. doi:10.3109/10641955.2013.872253