2001-05-03
Prevalence of tetraploid metaphases in semidirect and cultured chorionic villi
Publication
Publication
Fetal Diagnosis and Therapy , Volume 16 - Issue 3 p. 129- 132
Objective: Investigation of the normal frequency of tetraploid metaphases in semidirect (STC) and cultured (LTC) chorionic villi. Methods: Fifty metaphases in STC- and in LTC-villi slides of 100 women of advanced maternal age were screened for tetraploidy. Results: Up to three tetraploid metaphases were encountered in 27% of the STC-villi preparations; the scores fitted a Poisson distribution. In all LTC-villi preparations tetraploid cells were seen; the scores fitted a log-Gaussian distribution. Conclusions: On the basis of these distributions, we propose a protocol for the management of tetraploid metaphases in chorionic villi, strongly reducing the number of prenatal follow-up investigations. Copyright
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| doi.org/10.1159/000053896, hdl.handle.net/1765/66308 | |
| Fetal Diagnosis and Therapy | |
| Organisation | Department of Clinical Genetics |
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Noomen, P, van den Berg, C.D.F, de Ruyter, J.L.M, Van Opstal, A.R.M, & Los, F.J. (2001). Prevalence of tetraploid metaphases in semidirect and cultured chorionic villi. Fetal Diagnosis and Therapy, 16(3), 129–132. doi:10.1159/000053896
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