Clinical recurrences of Herpes simplex virus type 1 (HSV-1)-associated genital herpes are thought to be caused by reactivation of latent endogenous HSV-1. However, the possibility of reinfection with exogenous HSV-1 cannot be excluded. This study aimed to determine the incidence of genital HSV-1 superinfection in patients by investigating the genotype of sequential HSV-1 isolates obtained from the same anatomical site of patients with clinical recurrences of genital HSV-1 recurrent genital herpes. Sequential genital HSV-1 isolates were genotyped by PCR amplification of the hypervariable regions located within the HSV-1 genes US1 and US12. Whereas the sequential HSV-1 isolates in 11 of the 13 patients studied had the same genotypes, the sequential isolates of 2 patients showed a different genotype. The data suggest that HSV-1-induced recurrent genital herpes can be associated with genital reinfection with an exogenous HSV-1 strain.

Exogenous virus, Genital herpes, Genotype, PCR, Recurrence, Reinfection
dx.doi.org/10.1002/jmv.20132, hdl.handle.net/1765/66573
Journal of Medical Virology
Department of Dermatology

Roest, R.W, Carman, W.F, Maertzdorf, J, Scoular, A, Harvey, J, Kant, M, … Osterhaus, A.D.M.E. (2004). Genotypic analysis of sequential genital herpes simplex virus type 1 (HSV-1) isolates of patients with recurrent HSV-1 associated genital herpes. Journal of Medical Virology, 73(4), 601–604. doi:10.1002/jmv.20132