The putative pneumococcal proteinase maturation protein A is a potential pneumococcal vaccine candidate. We examined serum antipneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal proteinase maturation protein A antibodies is associated with pneumococcal contacts. A higher antipneumococcal proteinase maturation protein A antibody concentration at 18 months of age tends to predict for a lower risk of pneumococcal acute otitis media in the following 6 months (relative risk: 0.84, 95% confidence interval: 0.62-1.13).

Acute otitis media, PpmA, Streptococcus pneumoniae
dx.doi.org/10.1111/j.1574-695X.2005.00012.x, hdl.handle.net/1765/66622
F E M S Immunology and Medical Microbiology
Department of Pediatrics

Bogaert, D, Holmlund, G, Lahdenkari, M, de Groot, R, Kilpi, T, Hermans, P.W.M, & Kayhty, H. (2006). Development of antibodies against the putative proteinase maturation protein A in relation to pneumococcal carriage and otitis media. F E M S Immunology and Medical Microbiology, 46(2), 166–168. doi:10.1111/j.1574-695X.2005.00012.x