Chronic intervillositis (CI) and massive perivillous fibrin deposition (MFD), together with its related entity, maternal floor infarction (MFI), are rare and poorly understood placental lesions. Both MFD/MFI and CI are associated with poor fetal outcome and high risk of recurrence. We report a patient who was found to have both MFD and CI in the same placenta, resulting in severe intrauterine fetal growth restriction and intrauterine fetal death at 37 weeks of gestation. Characteristic histological findings included both very extensive perivillous deposition of fibrinoid material and a heavy infiltrate of CD68-positive macrophages/monocytes in the maternal intervillous space. To our knowledge, this is the first time the co-occurrence of MFD and CI is reported in the literature.

Chronic intervillositis, Intrauterine fetal death, Intrauterine growth restriction, Massive perivillous fibrin deposition, Maternal floor infarction,
Pediatric and Developmental Pathology
Department of Pathology

Weber, M, Nikkels, P.G.J, Hamoen, K, Duvekot, J.J, & de Krijger, R.R. (2006). Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: Case report. Pediatric and Developmental Pathology, 9(3), 234–238. doi:10.2350/06-01-0019.1