CD4+ T helper-2 (Th2) cells, which produce a unique profile of IL-4, IL-5 and IL-13 pro-inflammatory cytokines, are thought to be central in the orchestration and amplification of allergic asthma. However, a novel non-T/non-B lymphoid cell population, named type 2 innate lymphocytes (ILC2s), that produces high amounts of IL-5 and IL-13 was recently discovered. Unlike Th2 cells, these ILC2s are not antigen-restricted and are activated by epithelial cell-derived cytokines IL-25 and IL-33. In this review, we will focus on recent studies, mainly involving allergen-based mouse models, that have provided evidence for a significant contribution of ILC2 to allergic airway information.

Allergic airway inflammation, Cytokines, Gata3, HDM, House dust mite, IL-13, IL-25, IL-33, IL-5, Influenza, Innate lymphoid cells (ILC), Mouse models, TSLP, Type 2 innate lymphocytes
dx.doi.org/10.1007/s11882-013-0346-z, hdl.handle.net/1765/66809
Current Allergy & Asthma Reports
Department of Immunology

Klein Wolterink, R.G.J, & Hendriks, R.W. (2013). Type 2 innate lymphocytes in allergic airway inflammation. Current Allergy & Asthma Reports (Vol. 13, pp. 271–280). doi:10.1007/s11882-013-0346-z