Velo-cardio-facial syndrome (VCFS) is mostly associated with deletions of chromosome 22q11, and is thought to be characterized by an increased frequency of major psychiatric disorders. Sixteen patientsadults with VCFS and psychiatric symptoms were evaluated using a semi-structured investigation of history, symptoms, signs and behaviour. All available data were used in consensus meetings to obtain a classifiable diagnostic category. In contrast to other reports, no categorical diagnosis could be established. Instead, a quite specific psychological, behavioural and psychopathological constellation emerged that should most adequately be denominated as a VCFS-psychiatric syndrome. It is concluded that VCFS is associated with a specific psychopathological syndrome.

Behavioural phenotype, Intellectual disability, Psychiatric disorder, VCFS,
Annales de Genetique
Department of Psychiatry

Vogels, A, Verhoeven, W.M.A, Tuinier, S, Devriendt, K, Swillen, A, Curfs, L.M.G, & Frijns, J.P. (2002). The psychopathological phenotype of Velo-cardio-facial syndrome. Annales de Genetique, 45(2), 89–95. doi:10.1016/S0003-3995(02)01114-0