Role of dendritic cells and Th2 lymphocytes in asthma: Lessons from eosinophilic airway inflammation in the mouse
Microscopy Research and Technique , Volume 53 - Issue 4 p. 256- 272
Asthma is a chronic disorder of the airways characterized by variable airway narrowing, mucus hypersecretion, and infiltration of the airway wall with eosinophils. It is now believed that asthma is controlled by Th2 lymphocytes producing cytokines such as IL-4, IL-5, IL-9, and IL-13. Animal models of eosinophilic airway inflammation and airway hyperreactivity have been developed to study the contribution of cells or mediators in the pathogenesis of asthma. In this review, we discuss the role of antigen presenting cells, CD4+ and CD8+ T lymphocytes, B lymphocytes, NK cells, and mast cells in the induction and maintenance of eosinophilic airway inflammation, mucus hypersecretion, and airway hyperreactivity.
|Antigen presentation, Asthma, Dendritic cells, Eosinophilic airway inflammation, Mouse model, Pathophysiology, Th2 lymphocyte|
|Microscopy Research and Technique|
|Organisation||Department of Pulmonology|
van Rijt, L.S, & Lambrecht, B.N.M. (2001). Role of dendritic cells and Th2 lymphocytes in asthma: Lessons from eosinophilic airway inflammation in the mouse. Microscopy Research and Technique, 53(4), 256–272. doi:10.1002/jemt.1092