Purpose: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques. Methods and Materials: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk included the contralateral vocal cord, arytenoids, swallowing muscles, carotid arteries, and spinal cord. The prescription dose was 66 Gy in 33 fractions. Results: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose ± standard deviation to the planning target volume was 67 ± 1 Gy. The contralateral vocal cord dose was reduced from 66 ± 1 Gy in the conventional plans to 39 ± 8 Gy and 36 ± 6 Gy in the coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk. Conclusions: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates.

Early glottic carcinoma, Image-guided radiotherapy, Intensity-modulated radiotherapy, Normal tissue sparing, Quality of life
dx.doi.org/10.1016/j.ijrobp.2010.12.022, hdl.handle.net/1765/67001
International Journal of Radiation: Oncology - Biology - Physics
Department of Radiation Oncology

Osman, S.O.S, Astreinidou, E, de Boer, H.C.J, Keskin-Cambay, F, Breedveld, S, Voet, P.W.J, … Levendag, P.C. (2012). IMRT for image-guided single vocal cord irradiation. International Journal of Radiation: Oncology - Biology - Physics, 82(2), 989–997. doi:10.1016/j.ijrobp.2010.12.022