Regulation of gonadotropin receptor gene expression
Molecular and Cellular Endocrinology , Volume 100 - Issue 1-2 p. 15- 19
The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons. Alternative splicing of the large pre-mRNA of approximately 100 kb can result in mRNA species that encode truncated receptor proteins. In this review we discuss the regulation of gonadotropin receptor mRNA expression and the possible roles of alternative splicing in gonadotropin receptor function.
|Alternative splicing, Follicle-stimulating hormone receptor, Luteinizing hormone receptor, mRNA expression|
|Molecular and Cellular Endocrinology|
|Organisation||Department of Reproduction and Development|
Themmen, A.P.N, Kraaij, R, & Grootegoed, J.A. (1994). Regulation of gonadotropin receptor gene expression. Molecular and Cellular Endocrinology, 100(1-2), 15–19. doi:10.1016/0303-7207(94)90272-0