Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats
British Journal of Cancer , Volume 90 - Issue 9 p. 1830- 1832
Here we show that Doxil® has minimal antitumour activity in the isolated limb perfusion (ILP) setting and its activity was not enhanced by the addition of tumour necrosis factor (TNF). Doxil® accumulation in tumour tissue was low and also not augmented by TNF. In contrast, activity of free conventional doxorubicin was enhanced by TNF. We conclude that application of Doxil® in a TNF-based ILP is not a useful alternative to free conventional doxorubicin or melphalan.
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|British Journal of Cancer|
|Organisation||Department of Surgery|
ten Hagen, T.L.M, Hoving, S, Aan de Wiel-Ambagtsheer, G, van Tiel, S.T, & Eggermont, A.M.M. (2004). Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats. British Journal of Cancer, 90(9), 1830–1832. doi:10.1038/sj.bjc.6601688