2006-11-01
Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia
Publication
Publication
Cancer Cell , Volume 10 - Issue 5 p. 401- 411
Tribbles homolog 2 (Trib2) was identified as a downregulated transcript in leukemic cells undergoing growth arrest. To investigate the effects of Trib2 in hematopoietic progenitors, mice were reconstituted with hematopoietic stem cells retrovirally expressing Trib2. Trib2-transduced bone marrow cells exhibited a growth advantage ex vivo and readily established factor-dependent cell lines. In vivo, Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML). In mechanistic studies, we found that Trib2 associated with and inhibited C/EBPα. Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPα.
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| doi.org/10.1016/j.ccr.2006.09.012, hdl.handle.net/1765/67160 | |
| Cancer Cell | |
| Organisation | Department of Hematology |
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Keeshan, K., He, Y., Wouters, B., Shestova, O., Xu, L., Sai, H., Rodriguez, C., Maillard, I., Tobias, J., Valk, P., Carroll, M., Aster, J., Delwel, R.& Pear, W. (2006). Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia. Cancer Cell, 10(5), 401–411.https://doi.org/10.1016/j.ccr.2006.09.012 |
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