In an experimental study in growing rabbits an endolaryngeal injury to the subglottis resulted in the development of a stenosis due to the formation of scar tissue containing ectopic cartilage. For comparison, biopsies taken from the subglottic stenosis in 8 children were studied histologically. In 6 cases ectopic cartilage was observed; all patients had a history of endotracheal intubation. In 3 children the diagnosis hamartoma was made. In the remaining 3 cases the formation of ectopic cartilage might have been a direct reaction to the endolaryngeal intubation. The observations suggest that the formation of ectopic cartilage in acquired subglottic stenosis is not always due to a developmental aberration such as a hamartoma.

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International Journal of Pediatric Otorhinolaryngology
Department of Otorhinolaryngology

Adriaansen, F.C.P.M, Hoeve, L.J, Verwoerd-Verhoef, H.L, van der Heul, R.O, & Verwoerd, C.D.A. (1992). Ectopic cartilage in subglottic stenosis: Hamartoma or reaction to trauma?. International Journal of Pediatric Otorhinolaryngology, 23(3), 221–227. doi:10.1016/0165-5876(92)90103-V