In this retrospective study 351 children (<16.0 years) with end-stage renal disease (ESRD) accepted for renal replacement therapy (RRT) in the four Dutch pediatric centers were analyzed for the period 1987-2001. The data were compared with a previous study performed in 1979-1986. Eighty patients were of non-Dutch origin. An annual ESRD incidence of 5.8 patients per million of the child population (p.m.c.p.) was calculated, without significant changes with time. The final prevalence in Dutch children under 15 years of ESRD was 38.7 p.m.c.p. The most frequent primary renal disease leading to ESRD was urethral valves, with a significant increase vs. the previous observation period (14% vs. 6%). The distribution of primary renal diseases was similar in patients of non-Dutch origin and in Dutch patients. Peritoneal dialysis was the most frequent dialysis procedure initially applied (62% vs. 26% in the earlier observation period). Thirteen percent of all first transplantations (n=278) were pre-emptive and 19% from living donors. Five-year graft survival after a living-donor and a cadaver graft was 80% and 73%, respectively. Overall patient survival after 10 years on RRT was 94%.

Children, End-stage renal disease, Epidemiology, Etiology, Renal replacement therapy,
Pediatric Nephrology
Department of Pediatrics

Miklovicova, D, Cornelissen, M, Cransberg, K, Groothoff, J, Dedik, L, & Schroder, R. (2005). Etiology and epidemiology of end-stage renal disease in Dutch children 1987-2001. Pediatric Nephrology, 20(8), 1136–1142. doi:10.1007/s00467-005-1896-7