Adult-onset Still's disease is a systemic inflammatory disorder with a highly variable clinical course. Mild hepatitis and anemia are common manifestations. We describe a patient with adult Still's disease who developed a severe hepatitis and a life-threatening pure red cell aplasia. The hepatitis developed after treatment with NSAIDs was started. The patient was successfully treated with a combination of prednisone, cyclosporin, and methotrexate. Physicians should be aware that severe hepatitis and pure red cell aplasia can occur in adult Still's disease. We recommend a careful monitoring of liver functions in patients with adult Still's disease who are being treated with NSAIDs.

Additional Metadata
Keywords Hepatitis, NSAIDs, Pure red cell aplasia, Still's disease
Persistent URL dx.doi.org/10.1023/A:1026631514623, hdl.handle.net/1765/67276
Journal Digestive Diseases and Sciences
Citation
Janssen, H.L.A, van Laar, J.M, van Hoek, B, den Ottolander, G.J, van Krieken, J.H.J.M, & Breedveld, F.C. (1999). Severe hepatitis and pure red cell aplasia in adult Still's disease: Good response to immunosuppressive therapy. Digestive Diseases and Sciences, 44(8), 1639–1642. doi:10.1023/A:1026631514623