Kallmann syndrome and paranoid schizophrenia: A rare combination
Kallmann syndrome (KS) is a genetically heterogeneous and rare disorder characterised by the combination of hypothalamic hypogonadism and anosmia/hyposmia, a variable degree of intellectual disability and several somatic anomalies. In about one-third of the patients, mutations have been identified in at least seven different genes. Virtually no data are available about possible neuropsychiatric symptoms in KS. Here, a young adult male is described with a previous clinical diagnosis of KS and recent paranoid schizophrenia of which positive, but not negative symptoms, fully remitted upon treatment with antipsychotics. Neither genome-wide array analysis nor mutation analyses disclosed imbalances or mutations in any of presently known KS disease genes. This is the first report on a patient with KS and paranoid schizophrenia in whom extensive genetic analyses were performed. It is concluded that further studies are warranted in order to elucidate a possible increased risk for psychiatric symptoms in patients with KS.Copyright 2013 BMJ Publishing Group. All rights reserved.
|BMJ Case Reports|
|Organisation||Department of Psychiatry|
Verhoeven, W.M.A, Egger, J.I.M, Hovens, J.E.J.M, & Hoefsloot, E.H. (2013). Kallmann syndrome and paranoid schizophrenia: A rare combination. BMJ Case Reports. doi:10.1136/bcr-2012-007387