Thirty-year-old observations report frequent asymptomatic Clostridium difficile carriage among cystic fibrosis (CF) patients. In this case-control study, we found more carriers among CF patients than controls (47% versus 11%), but most strains carried by CF patients were non-toxigenic (77% versus 17%). Among CF patients, carriers were younger, with more severe pulmonary disease than non-carriers. Strains belonged to multiple PCR-ribotypes, suggesting that these CF patients did not acquire strains from each other. Clinical Microbiology and Infection

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doi.org/10.1111/1469-0691.12439, hdl.handle.net/1765/67310
Clinical Microbiology and Infection
Department of Pulmonology

Bauer, M.P, Farid, W.R.R, Bakker, M, Hoek, R.A.S, Kuijper, E, & van Dissel, J.T. (2014). Patients with cystic fibrosis have a high carriage rate of non-toxigenic Clostridium difficile. Clinical Microbiology and Infection, 20(7). doi:10.1111/1469-0691.12439