Thirty-year-old observations report frequent asymptomatic Clostridium difficile carriage among cystic fibrosis (CF) patients. In this case-control study, we found more carriers among CF patients than controls (47% versus 11%), but most strains carried by CF patients were non-toxigenic (77% versus 17%). Among CF patients, carriers were younger, with more severe pulmonary disease than non-carriers. Strains belonged to multiple PCR-ribotypes, suggesting that these CF patients did not acquire strains from each other. Clinical Microbiology and Infection

Asymptomatic carriage, CFTR mutations, Clostridium difficile, Cystic fibrosis, PCR ribotypes,
Clinical Microbiology and Infection
Department of Pulmonology

Bauer, M.P, Farid, W.R.R, Bakker, M, Hoek, R.A.S, Kuijper, E, & van Dissel, J.T. (2014). Patients with cystic fibrosis have a high carriage rate of non-toxigenic Clostridium difficile. Clinical Microbiology and Infection, 20(7). doi:10.1111/1469-0691.12439