Intravascular ultrasound evaluation after sirolimus eluting stent implantation for de novo and in-stent restenosis lesions
European Heart Journal , Volume 25 - Issue 1 p. 32- 38
Aims: The aim of this study is to compare the efficacy of sirolimus-eluting stents (SES) on neointimal growth and vessel remodelling for in-stent restenosis versus de novo coronary artery lesions using serial intravascular ultrasound (IVUS). Methods and results: The study population consisted of 86 patients with in-stent restenosis (ISR) (n=41) or de novo lesions (n=45) treated with SES and evaluated by IVUS post-procedure and at follow-up. One 18-mm SES was used for de novo lesions while 16 patients with ISR received >1 SES (total stented length 17.9 mm vs 22.0 mm respectively; P=0.004). At follow-up, no differences were observed between the ISR and de novo groups with respect to changes in the mean external elastic membrane (1.7% vs 1.3%; P=0.53), plaque behind the stent (1.2% vs 3.4%; P=0.49), and lumen areas (0.7% vs 1.9%; P=0.58). No positive remodelling or edge effect was observed. A gap between stents was observed in two patients with ISR, where more prominent, though non-obstructive, neointimal proliferation was noted. Conclusion: Sirolimus-eluting stenting is equally effective at inhibiting neointimal proliferation in de novo and ISR lesions without inducing edge restenosis or positive vascular remodelling.
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|European Heart Journal|
|Organisation||Department of Cardiology|
Degertekin, M, Lemos Neto, P.A, Lee, C.H, Tanabe, K, Sousa, J.E, Abizaid, A.C, … Serruys, P.W.J.C. (2004). Intravascular ultrasound evaluation after sirolimus eluting stent implantation for de novo and in-stent restenosis lesions. European Heart Journal, 25(1), 32–38. doi:10.1016/j.ehj.2003.10.012