Introduction: The association between cardiac autonomic and left ventricular (LV) dysfunction in Chagas disease (ChD) is controversial. Methods: A standardized protocol that includes the Valsalva maneuver, a respiratory sinus arrhythmia (RSA) test, and an echocardiographic examination was used. Spearman correlation coefficients (rho) were used to investigate associations. Results: The study population consisted of 118 ChD patients undergoing current medical treatment, with an average LV ejection fraction of 51.4±2.6%. The LV ejection fraction and diastolic dimension were correlated with the Valsalva index (rho=0.358, p<0.001 and rho=-0.266, p=0.004, respectively) and the RSA (rho=0.391, p<0.001 and rho=-0.311, p<0.001, respectively). Conclusions: The impairment of LV function is directly associated with a reduction of cardiac autonomic modulation in ChD.

Autonomic function, Chagas disease, Valsalva index
dx.doi.org/10.1590/0037-8682-0013-2013, hdl.handle.net/1765/67473
Revista da Sociedade Brasileira de Medicina Tropical
Department of Medical Microbiology and Infectious Diseases

Raadschilders, L, Rocha, M.O.C, Sousa, L, Nouwen, J.L, & Ribeiro, A.L. (2014). Is autonomic function associated with left ventricular systolic function in Chagas heart disease patients undergoing treatment for heart failure?. Revista da Sociedade Brasileira de Medicina Tropical, 47(2), 239–242. doi:10.1590/0037-8682-0013-2013