Introduction: The association between cardiac autonomic and left ventricular (LV) dysfunction in Chagas disease (ChD) is controversial. Methods: A standardized protocol that includes the Valsalva maneuver, a respiratory sinus arrhythmia (RSA) test, and an echocardiographic examination was used. Spearman correlation coefficients (rho) were used to investigate associations. Results: The study population consisted of 118 ChD patients undergoing current medical treatment, with an average LV ejection fraction of 51.4±2.6%. The LV ejection fraction and diastolic dimension were correlated with the Valsalva index (rho=0.358, p<0.001 and rho=-0.266, p=0.004, respectively) and the RSA (rho=0.391, p<0.001 and rho=-0.311, p<0.001, respectively). Conclusions: The impairment of LV function is directly associated with a reduction of cardiac autonomic modulation in ChD.

Autonomic function, Chagas disease, Valsalva index,
Revista da Sociedade Brasileira de Medicina Tropical
Department of Medical Microbiology and Infectious Diseases

Raadschilders, L, Rocha, M.O.C, Sousa, L, Nouwen, J.L, & Ribeiro, A.L. (2014). Is autonomic function associated with left ventricular systolic function in Chagas heart disease patients undergoing treatment for heart failure?. Revista da Sociedade Brasileira de Medicina Tropical, 47(2), 239–242. doi:10.1590/0037-8682-0013-2013