Background. Cervical lymphoepithelioma-like carcinoma (LELC) is a rare variant of squamous cell carcinoma of the cervix. Association with Epstein-Barr virus (EBV) is still controversial. EBV has been demonstrated in Asian women with cervical LELC. In Western women, human papillomavirus (HPV) might play a role in the etiology. Case. We describe a 44-year-old Caucasian woman with a lymphoepithelioma-like carcinoma of the cervix without EBV, but in the presence of multiple HPV infection. Conclusion. Our case supports a possible different pathway of development of cervical LELC in Western women as compared to Asian women.

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Gynecologic Oncology
Department of Pathology

Bais, A., Kooi, S., Teune, T., Ewing, P., & Ansink, A. (2005). Lymphoepithelioma-like carcinoma of the uterine cervix: Absence of Epstein-Barr virus, but presence of a multiple human papillomavirus infection. Gynecologic Oncology, 97(2), 716–718. doi:10.1016/j.ygyno.2005.01.016