Objective - Phytoestrogens have been postulated to protect against cardiovascular diseases, but few studies have focused on the effect of Western dietary phytoestrogen intake. Methods and Results - Four hundred three women with natural menopause either between 1987 and 1989 or between 1969 and 1979 were selected from the baseline data of the PROSPECT study (n = 17 395). Isoflavone and lignan intake was calculated from a food-frequency questionnaire. Aortic stiffness was noninvasively assessed by pulse-wave velocity measurement of the aorta. Linear regression analysis was used. After adjustment for age, body mass index, smoking, physical activity, mean arterial pressure, follow-up time, energy intake, dietary fiber intake, glucose, and high density lipoprotein cholesterol, increasing dietary isoflavone intake was associated with decreased aortic stiffness: -0.51 m/s (95% CI - 1.00 to -0.03, fourth versus first quartile, P for trend=0.07). Increasing dietary intake of lignans was also associated with decreased aortic pulse-wave velocity: -0.42 m/s (95% CI -0.93 to 0.11, fourth versus first quartile, P for trend=0.06). Results were most pronounced in older women: for isoflavones, -0.94 m/s (95% CI - 1.65 to -0.22, P for trend=0.02), and for lignans, -0.80 m/s (95% CI -1.85 to -0.05), fourth versus first quartile. Conclusions - The results of our study support the view that phytoestrogens have a protective effect on the risk of atherosclerosis and arterial degeneration through an effect on arterial walls, especially among older women.

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doi.org/10.1161/01.ATV.0000027176.83618.1A, hdl.handle.net/1765/67556
Arteriosclerosis, Thrombosis, and Vascular Biology
Erasmus MC: University Medical Center Rotterdam

van der Schouw, Y., Pijpe, A., Lebrun, C., Bots, M., Peeters, P., van Staveren, W., … Grobbee, D. (2002). Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(8), 1316–1322. doi:10.1161/01.ATV.0000027176.83618.1A