The prevalence of coexistent diseases in addition to breast cancer becomes increasingly important in an ageing population. However, the clinical implications are unclear. The age-specific prevalence of serious comorbidity among all new breast cancer patients diagnosed from 1995 to 2001 (n = 8966) in the South of the Netherlands was analysed in relation to age, stage and treatment. Independent prognostic effects of age and comorbidity were evaluated (follow-up was continued until 1 January 2004). The prevalence of comorbidity increased from 9% for those aged <50 years to 56% for patients aged 80+ years. The most frequent conditions were cardiovascular disease (7%), diabetes mellitus (7%), and previous cancer (6%). In the presence of comorbidity, fewer patients received radiotherapy (51% vs. 66%, P < 0.0001) and fewer patients who underwent breast-conserving surgery also had axillary dissection (P < 0.0001). Relative 5-year survival rates for patients without comorbidity (87%) were significantly higher (P < 0.01) than those for patients with previous cancer (77%), diabetes mellitus (78%), and for patients with 2+ coexistent diseases (59%). Relative survival of patients without comorbidity increased with age to 93% for patients older than 70 years. Comorbidity negatively affected prognosis, independent of age, stage of disease, and treatment (Hazard Ratio (HR) = 1.3, P = 0.0001 for one coexistent disease and HR = 1.4, P = 0.0001 for 2+ coexistent diseases). The most important effects were found for previous cancer (HR = 1.4, P = 0.003), cerebrovascular disease (HR = 1.6, P < 0.004) or dementia (HR = 2.3, P < 0.0001). Elderly breast cancer patients can be divided in those without other diseases, who have a relatively good prognosis, and those who have at least one other serious coexistent disease and significantly poorer prognosis.

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Keywords Breast cancer, Comorbidity, Elderly, Long-term prognosis, Treatment
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Journal European Journal of Cancer
Louwman, M.W.J, Janssen-Heijnen, M.L.G, Houterman, S, Voogd, A.C, van der Sangen, M.J.C, Nieuwenhuijzen, G.A.P, & Coebergh, J.W.W. (2005). Less extensive treatment and inferior prognosis for breast cancer patient with comorbidity: A population-based study. European Journal of Cancer, 41(5), 779–785. doi:10.1016/j.ejca.2004.12.025