Dientamoeba fragilis is a debated protozoan parasite that is often detected in stools of patients with chronic gastro-intestinal complaints. A retrospective follow-up study of a large cohort of patients was performed to better understand the natural course of the infection and possible treatment options. D. fragilis was spontaneously cleared in 41% of untreated cases. With an eradication rate of 98%, treatment with paromomycin appeared more effective than treatment with clioquinol (83%) or metronidazole (57%).

Diarrhea, Dientamoeba fragilis, Metronidazole, Parasite
dx.doi.org/10.1016/j.ijpddr.2012.03.002, hdl.handle.net/1765/67859
International Journal for Parasitology: Drugs and Drug Resistance
Department of Medical Microbiology and Infectious Diseases

van Hellemond, J.J, Molhoek, N, Koelewijn, R, Wismans, P.J, & van Genderen, P.J.J. (2012). Is paromomycin the drug of choice for eradication of Dientamoeba fragilis in adults?. International Journal for Parasitology: Drugs and Drug Resistance, 2, 162–165. doi:10.1016/j.ijpddr.2012.03.002