DNA damage response
Cold Spring Harbor Perspectives in Biology , Volume 3 - Issue 1 p. 1- 19
Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network ofDNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required.
|Cold Spring Harbor Perspectives in Biology|
|Organisation||Department of Molecular Genetics|
Giglia-Mari, G, Zotter, A, & Vermeulen, W. (2011). DNA damage response. Cold Spring Harbor Perspectives in Biology, 3(1), 1–19. doi:10.1101/cshperspect.a000745