Background: 'Wet-wrap' dressings with diluted corticosteroids form an alternative treatment in patients with refractory atopic dermatitis (AD). Objective: To evaluate a standardized treatment, using wet-wrap dressings with diluted corticosteroids, in patients with refractory AD. Methods: Results of treatment, complications and possible side effects were retrospectively evaluated in 14 children and 12 adults. Results: Skin lesions improved dramatically during 1 week of inpatient treatment. A significant decrease in early-morning serum cortisol levels was measured. Levels below the normal range were only observed after 1 week in 2 adults and on day 4 in 3 children. Suppression of the hypothalamus-pituitary-adrenal-cortex axis in 1 adult and a new exacerbation of AD in 2 children and 3 adults complicated long-term treatment at home. Additional complications included folliculitis, a Pseudomonas aeruginosa infection, a secondary bacterial infection and refractory skin lesions between bandages. Conclusion: Wet-wrap dressings and diluted corticosteroids form an effective treatment in patients with refractory AD. Copyright

'Wet-wrap' dressings, Atopic dermatitis
dx.doi.org/10.1159/000051810, hdl.handle.net/1765/67991
Dermatology: international journal for clinical and investigative dermatology
Department of Dermatology

Devillers, A.C.A, de Waard-van der Spek, F.B, Mulder, P.G.H, & Oranje, A.P. (2002). Treatment of refractory atopic dermatitis using 'wet-wrap' dressings and diluted corticosteroids: Results of standardized treatment in both children and adults. Dermatology: international journal for clinical and investigative dermatology, 204(1), 50–55. doi:10.1159/000051810