Hypereosinophilic syndrome in children
Leukemia Research: clinical and laboratory studies , Volume 36 - Issue 10 p. 1249- 1254
Recently, according to the Hypereosinophilic Diseases Working Group of the International Eosinophil Society, six variants of hypereosinophilic syndrome have been proposed, i.e. (1) myeloproliferative, (2) lymphoproliferative, (3) idiopathic/undefined, (4) overlapping, (5) associated and (6) familial variant. Hypereosinophilic syndrome is a rare disorder in children and can occur at any age during childhood. Corticosteroids are the treatment of choice, whereas other treatment options are hydroxyurea, IFNα, imatinib, vincristine, mepolizumab. We present a fulminant fatal case of hypereosinophilic syndrome in a teenager with an initial presentation of an idiopathic thrombocytopenia (ITP) and present a narrative review of literature.
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van Grotel, M, de Hoog, M, de Krijger, R.R, Beverloo, H.B, & van den Heuvel-Eibrink, M.M. (2012). Hypereosinophilic syndrome in children. Leukemia Research: clinical and laboratory studies, 36(10), 1249–1254. doi:10.1016/j.leukres.2012.05.025