Aim: To observe reactogenicity of a three-component acellular pertussis (aP) vaccine simultaneously given with dT-IPV vaccine at the age of 4 years. Results: Of 813 subjects 36% had no adverse events. At the first day the score for pain was 47-55% (aP versus dT-IPV), for redness 3-4% and for swelling 5-6%. Irritability and loss of appetite had a score of 20%. In 3% of the children fever was present. Most symptoms disappeared within 3 days. Conclusion: Boostervaccination with an aP vaccine simultaneously given with dT-IPV vaccine at the age of 4 years is well tolerated.

Additional Metadata
Keywords Acellular pertussis vaccine, Booster vaccination, Reactogenicity
Persistent URL dx.doi.org/10.1016/j.vaccine.2004.03.010, hdl.handle.net/1765/68155
Journal Vaccine
Citation
Keijzer-Veen, M.G, Holty-Van Der Wekken, L, Juttmann, R.E, de Groot, R, & Rümke, H. (2004). Reactogenicity of acellular pertussis vaccine in 4-year-olds in The Netherlands. Vaccine, 22(25-26), 3256–3257. doi:10.1016/j.vaccine.2004.03.010