2013-08-01
In vitro assessment of the immunological significance of a human monoclonal antibody directed to the influenza a virus nucleoprotein
Publication
Publication
Clinical and Vaccine Immunology (Print) , Volume 20 - Issue 8 p. 1333- 1337
Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity, or opsonization of viral antigen for improved antigen presentation to CD8 + T cells by dendritic cells. Copyright
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| doi.org/10.1128/CVI.00339-13, hdl.handle.net/1765/68180 | |
| Clinical and Vaccine Immunology (Print) | |
| Organisation | Department of Virology |
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Bodewes, R., Geelhoed-Mieras, M., Wrammert, J., Ahmed, R., Wilson, P., Fouchier, R., … Rimmelzwaan, G. (2013). In vitro assessment of the immunological significance of a human monoclonal antibody directed to the influenza a virus nucleoprotein. Clinical and Vaccine Immunology (Print), 20(8), 1333–1337. doi:10.1128/CVI.00339-13 |
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