Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity, or opsonization of viral antigen for improved antigen presentation to CD8 + T cells by dendritic cells. Copyright

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Persistent URL dx.doi.org/10.1128/CVI.00339-13, hdl.handle.net/1765/68180
Journal Clinical and Vaccine Immunology (Print)
Citation
Bodewes, R, Geelhoed-Mieras, M.M, Wrammert, J, Ahmed, R, Wilson, P.C, Fouchier, R.A.M, … Rimmelzwaan, G.F. (2013). In vitro assessment of the immunological significance of a human monoclonal antibody directed to the influenza a virus nucleoprotein. Clinical and Vaccine Immunology (Print), 20(8), 1333–1337. doi:10.1128/CVI.00339-13