Maneb, manganese ethylene-bis-dithiocarbamate, is a fungicide pesticide used in the agriculture and bulb flower culture sector. Toxicological effects for humans have been reported in literature and are diverse. They vary from allergic reactions (dermatitis, conjunctivitis, and bronchitis), central nervous system effects (muscarinic, nicotinic, central and extrapyramidal) and renal toxicity (acute renal failure).A 7-year old girl was admitted to the pediatric intensive care unit because of status epilepticus. Physical examination showed respiratory insufficiency, convulsions, and severe hypothermia (32.5°C). The patient was intubated and her convulsions were successfully treated with benzodiazepines. Except for a combined metabolic and respiratory acidosis and hyperglycemia, diagnostic investigations on admission (full blood count, electrolytes, liver and renal functions, cerebrospinal fluid investigation, toxicology screening of blood and urine for barbiturates and benzodiazepines, blood culture, herpes PCR, and a CT scan of the brain) were normal. Within 24 hours, there was a complete recovery of all neurological signs. Within 72 hours, the patient was discharged from the hospital. Liquid chromatography-mass spectrometric investigation of her blood showed amounts of maneb, which can explain all symptoms and signs. However, effects of this magnitude on the central nervous system have not previously been reported in humans.

Coma, Convulsions, Hypothermia, Intoxication, Maneb
dx.doi.org/10.1097/01.ftd.0000243964.90340.cc, hdl.handle.net/1765/68188
Therapeutic Drug Monitoring
Department of Pediatrics

de Tollenaer, S.M, Buysse, C.M.P, van den Anker, J.N, Touw, D.J, & de Hoog, M. (2006). Life threatening central nervous system manifestations and hypothermia due to maneb intoxication in a child: A case report. In Therapeutic Drug Monitoring (Vol. 28, pp. 813–815). doi:10.1097/01.ftd.0000243964.90340.cc