Objectives: Thrombotic complications are common in vascular surgery patients. Non-O blood types are associated with an increased risk of thrombo-embolic diseases. The aim of this study is to assess the prognostic implications of non-O vs. O blood type regarding 30-day cardiovascular events and long-term mortality after vascular surgery. Methods: The population of this retrospective cohort study consisted of 4679 patients undergoing elective major vascular surgery between the years 1990 and 2011. Baseline characteristics, ABO blood type and follow-up were obtained. Multivariable regression analyses, adjusted for age, gender, medical history, medication and smoking were used to evaluate the impact of non-O blood type on 30-day cardiovascular events (cardiovascular death, myocardial infarction and stroke) and long-term mortality. Results: Non-O blood type was present in 2627 (56%) patients. Within 30 days after surgery, 129 (4.9%) non-O and 112 (5.5%) O patients suffered a cardiovascular event (P = 0.42). Non-O blood type was not associated with increased mortality during long-term follow-up (adjusted hazard ratio (aHR) 0.96; 95% confidence interval (CI) 0.88-1.04, with a median follow-up of 4 years). Anti-platelet and anticoagulant drugs did not interact with the relationship between ABO blood type and long-term outcome. Conclusion: Non-O blood type is not associated with either 30-day cardiovascular complications or long-term mortality in vascular surgery patients.

ABO blood-group system, Cardiovascular complications, Mortality, Vascular surgical procedures
dx.doi.org/10.1016/j.ejvs.2012.11.022, hdl.handle.net/1765/68456
European Journal of Vascular and Endovascular Surgery
Department of Surgery

Bakker, E.J, Valentijn, T.M, Hoeks, S.E, van de Luijtgaarden, K.M, Leebeek, F.W.G, Verhagen, H.J.M, & Stolker, R.J. (2013). ABO blood type does not influence the risk of cardiovascular complications and mortality after vascular surgery. European Journal of Vascular and Endovascular Surgery, 45(3), 256–260. doi:10.1016/j.ejvs.2012.11.022