Outcome of implantable cardioverter defibrillators in adults with congenital heart disease: A multi-centre study
European Heart Journal , Volume 28 - Issue 15 p. 1854- 1861
Aims: To investigate outcome and complications of implantable cardioverter defibrillators (ICDs) in adults with congenital heart disease (CHD) and to identify predictors of (in-) appropriate shocks. Methods and results: Sixty-four CHD patients ≥ 18 years at first ICD implantation [63% tetralogy of Fallot (TOF) and age at implantation 37 ± 13 years] were identified using the Dutch adult CHD registry and a Belgian tertiary care centre database. Median follow-up duration was 3.7 years. Early complications included pocket haematoma (n = 3), lead failure (n = 2), and pneumothorax (n = 2). Late complications occurred in 11 (17%) patients, including lead failure (n = 6) and and electrical storm (n = 3). Overall, 30 device-related re-interventions were performed in 20 patients (31%), including four premature generator changes and seven lead replacements. Half of the patients received one or more shocks, and 46 shocks in 15 patients (23%) were classified as appropriate. One hundred and sixty shocks in 26 patients (41%) were classified as inappropriate. No predictors of (in-)appropriate shocks were identified, except TOF being associated with less appropriate shocks than patients with other CHD (HR 0.29, P = 0.02). Conclusion: The ICD provided effective therapy in a quarter of adults with CHD with low complication rates. The incidence of inappropriate shocks, however, appeared to be excessive and warrants further attention.
|Adults, Congenital heart disease, Implantable defibrillators, Sudden cardiac death, Tetralogy of Fallot|
|European Heart Journal|
|Organisation||Department of Cardiology|
Yap, S.C, Roos-Hesselink, J.W, Hoendermis, E.S, Budts, W, Vliegen, H.W, Mulder, B.J.M, … Drenthen, W. (2007). Outcome of implantable cardioverter defibrillators in adults with congenital heart disease: A multi-centre study. European Heart Journal, 28(15), 1854–1861. doi:10.1093/eurheartj/ehl306