2012-02-01
Human endogenous retrovirus K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected in HIV-1-infected subjects using standard peptide matrix-based screening
Publication
Publication
Clinical and Vaccine Immunology (Print) , Volume 19 - Issue 2 p. 288- 292
T-cell responses to human endogenous retrovirus (HERV) K(HML-2) Gag and Env were mapped in HIV-1-infected subjects using 15mer peptides. Small peptide pools and high concentrations were used to maximize sensitivity. In the 23 subjects studied, only three bona fide HERV-K(HML-2)-specific responses were detected. At these high peptide concentrations, we detected falsepositive responses, three of which were mapped to an HIV-1 Gag peptide contaminant. Thus, HERV-K(HML-2) Gag- and Envspecific T-cell responses are infrequently detected by 15mer peptide mapping. Copyright
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| doi.org/10.1128/CVI.05583-11, hdl.handle.net/1765/68782 | |
| Clinical and Vaccine Immunology (Print) | |
| Organisation | Department of Neurology |
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Jones, R. B., John, V., Hunter, D., Martin, E., Mujib, S., Mihajlovic, V., Burgers, P., Luider, T., Gyenes, G., Sheppard, N., SenGupta, D., Tandon, R., Yue, F.-Y., Benko, W., Kovacs, C., Nixon, R.& Ostrowski, M. (2012). Human endogenous retrovirus K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected in HIV-1-infected subjects using standard peptide matrix-based screening. Clinical and Vaccine Immunology (Print), 19(2), 288–292.https://doi.org/10.1128/CVI.05583-11 |
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