Introduction: We tested the feasibility of using a novel contrast agent, MS-325, as a marker of coagulating tissue during thermoablative treatment. Materials and Methods: In vivo, we created coagulated lesions in porcine muscle tissue under 3 different conditions: MS-325 (n = 5), gadolinium-DTPA (n = 5), or no contrast agent (n = 9) present during laser thermoablation. At the same time, we performed continuous T1-weighted magnetic resonance imaging at 1.5 T. We quantified the change in signal intensity during treatment expressed as relative enhancement, and compared the 3 groups by using Mann-Whitney analysis. Results: MS-325 resulted in a more than 3.2-fold increase in relative enhancement over the gadolinium-DTPA and noncontrast control groups (P < 0.008). Conclusion: MS-325 appears to be a valid marker for coagulating tissue and significantly increased relative enhancement of the treated lesions when compared with both Gd-DTPA and noncontrast-enhanced conditions. MS-325 thus has potential for monitoring of thermoablative treatment.

Animals, Lasers, Magnetic resonance, MR contrast media, MR thermometry
dx.doi.org/10.1097/00004424-200411000-00003, hdl.handle.net/1765/68798
Investigative Radiology: a journal of clinical and laboratory research
Department of Neuroscience

Vogel, M.W, Entius, C.A, & Pattynama, P.M.T. (2004). Monitoring tissue coagulation during thermoablative treatment by using a novel magnetic resonance imaging contrast agent. Investigative Radiology: a journal of clinical and laboratory research, 39(11), 661–665. doi:10.1097/00004424-200411000-00003